macrocytic anemias การใช้

• Workers exposed to high levels are at risk for granulocytopenia, macrocytic anemia, oligospermia, and azoospermia.
• Macrocytic anemia is not a disease in the sense of having a single pathology but, rather, is a condition.
• As expected, a defect at any point of the aforementioned list, can cause malabsoption of vitamin B12, and subsequent macrocytic anemia.
• Diseases associated with folic acid deficiency include : megaloblastic or macrocytic anemia, cardiovascular disease, certain types of cancer, and NTDs in infants.
• Serum B12, Malonic Acid, Schilling Test, Complete Blood Count-looking for megaloblastic anemia if there is also folic acid deficiency or macrocytic anemia
• In a macrocytic anemia, the larger red cells are always associated with insufficient " numbers " of cells and often also insufficient hemoglobin content per cell.
• Deficiencies of Vitamin B 12 or folate produce a macrocytic anemia ( large cell anemia ) in which the RDW is elevated in roughly two-thirds of all cases.
• Other causes that are typically thought of as causing normocytic anemia or macrocytic anemia must also be considered, and the presence of two or more causes of anemia can distort the typical picture.
• The normal mean corpuscular volume ( abbreviated to MCV on fL, with smaller cells ( 100 fL ) as macrocytic ( the latter occur in macrocytic anemia ) . The MCV is the average red blood cell size.
• Folate supplementation is beneficial in patients being treated with long-term, low-dose methotrexate for inflammatory conditions, such as rheumatoid arthritis ( RA ) or psoriasis, to avoid macrocytic anemia caused by folate deficiency.
• In patients with anemia, it is the MCV measurement that allows classification as either a microcytic anemia ( MCV below normal range ), normocytic anemia ( MCV within normal range ) or macrocytic anemia ( MCV above normal range ).
• Especially common causes of macrocytic anemias are the so-called megaloblastic anemias, in which cells are larger because they cannot produce DNA quickly enough to divide at the right time as they grow and thus grow too large before division.
• Vitamin B 12 is an essential water-soluble vitamin, the deficiency of which creates anemia ( macrocytic anemia ), decreased bone marrow cell production ( anemia, pancytopenia ), neurological problems, as well as metabolic issues ( methylmalonyl-CoA acidosis ).
• *Deoxyadenosyl B 12 or as it is sometimes referred to Ado B 12 : Ado B 12 is essential for acid-base maintenance of the blood, simply because Ado B 12 is the catalyst that assists the conversion of, Methylmalonyl CoA, into Succinyl CoA . In absence of vitamin B 12, levels of Methylmalonyl CoA increase, and this is in fact a great way to distinguish folate deficiency macrocytic anemia, from vitamin B 12 anemia.